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>> 程蜀琳教授

程蜀琳:

上海交通大学致远讲席教授,芬兰于韦斯屈拉大学运动健康学院教授。

研究方向:

家族跟踪研究骨代谢、脂代谢和糖代谢之间的交互作用及代谢性疾病运动膳食干预效果及机制。

联系方式:

sulin.cheng@jyu.fi

      长期在健康科学与技术领域开展科学研究,涉及应用基础研究、与健康科技相关的技术开发项目、与体育锻炼营养干预、改善身体健康状况和日常活动功效等方面的研究。这些研究均为人群研究。将多种体质、神经肌肉、心血管和激素、脂代谢、骨代谢和糖代谢等相关人体指标整合起来作为评估人体体质和健康及运动能力的标准。研究包括健康人群、儿童、老年人、肥胖伴有代谢性疾病人群和运动员等。此外,近年来做了大量涉及健康、运动、康复方面的测试仪器、健身和康复的器材、营养品的促进应用研究和产品开发的工作。

      在同行评议的国际学术期刊上发表了130多篇SCI研究论文,其中第一作者23篇,通讯作者67篇,影响因子超过7的论文有17篇,影响因子5-7的论文有14篇,影响因子3-5的论文有36篇论文。发表的国际期刊论文包括自然遗传杂志(Nature Genetics)、循环杂志(Circulation)和肝脏杂志(Journal of Hepatology)。2012年有关糖脂代谢与骨代谢的研究被Nature Review Endocrinology作为新陈代谢热点研究进行报道。2014年肠道菌与脂肪肝的研究论文作为Journal of Hepatolog的封面文章并写序向同行推荐。

      获得过8个国际科学奖和6个国家奖项。其中Calex研究成果被选入美国医生再教育教材,用于芬兰卫生部关于少年儿童的营养健康指南。

      拥有有三項与诊断监测骨质疏松和肌肉活动的发明专利和一项正在申请的合作条约专利。

> 近三年发表的学术论文及代表性论文:
Peer-reviewed scientific articles (*corresponding author)
1 Wang Q, Chen D, Cheng SM, Nicholson P, Alen M, *Cheng S. Growth and aging of proximal femoral bone - a study with women spanning three generations. J Bone Miner Res. 2014 Sep 6. doi: 10.1002/jbmr.2353. [Epub ahead of print]
2 Munukka E, Pekkala S, Wiklund P, Rasool O, Borra R, Kong L, Ojanen X, Cheng SM, Roos C, Tuomela S, Alen M, Lahesmaa R, *Cheng S. Gut-adipose tissue axis in hepatic fat accumulation in humans. J Hepatol. 61:132-138,2014
3 Wang Q, Chen D, Nicholson P, Cheng SM, Alen M, Mao L, *Cheng S. The Associations of Serum Serotonin with Bone Traits are Age- and Gender-specific. PLoS One. 3;9(10):e109028. doi: 10.1371/journal.pone.0109028. eCollection 2014. Wiklund PK, Pekkala SP, Autio R, Munukka E, Xu L, Saltevo J, Cheng SM, Kujala U, Alen A, *Cheng S. Serum metabolic profiles in overweight and obese women with and without metabolic syndrome. Diabetology& Metabolic Syndrome.6:40-48, 2014.
4 Wen X, Pekkala S, Wang R, Wiklund P, Feng G, Mei Cheng S, Tan X, Liu Y, Chen P, Eriksson JG, Alen M, *Cheng S. Does systemic low-grade inflammation associate with fat accumulation and distribution? - A 7-year follow-up study with peripubertal girls. J Clin Endocrinol Metab. 99:1411-1419,2014.
5 Wiklund P, Alen M, Munukka E, Cheng SM, Pekkala S, *Cheng S. Metabolic response to six week aerobic exercise training and dieting in previously sedentary overweight and obese premenopausal women: A Randomized Trial. JSHS 3:217-224,2014.
6 Liu WY, Lu DJ, Du XM, Sun JQ, Ge J, Wang RW, Wang R, Zou J, Xu C, Ren J, Wen XF, Liu Y, Cheng SM, Tan X, Pekkala S, Munukka E, Wiklund P, Chen YQ, Gu Q, Xia ZC, Liu JJ, Liu WB, Chen XB, Zhang YM, Li R, Borra RJH, Yao JX, Chen PJ, *Cheng S. Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men – the role of gut microbiota composition: study protocol for the AELC randomized controlled trial. BMC Public Health.14:48-59,2014.
7 Moayyeri A, Hsu YH, Karasik D, Estrada K, Xiao SM, Nielson C, Srikanth P, Giroux S, Wilson SG, Zheng HF, Smith AV, Pye SR, Leo PJ, Teumer A, Hwang JY, Ohlsson C, McGuigan F, Minster RL, Hayward C, Olmos JM, Lyytikäinen LP, Lewis JR, Swart KM, Masi L, Oldmeadow C, Holliday EG, *Cheng S, van Schoor NM, Harvey NC, Kruk M, Fabiola Del Greco M, Igl W, Trummer O, Grigoriou E, Luben R, Liu CT, Zhou Y, Oei L, Medina-Gomez C, Zmuda J, Tranah G, Brown SJ, Williams FM, Soranzo N, Jakobsdottir J, Siggeirsdottir K, Holliday KL, Hannemann A, Go MJ, Garcia M, Polasek O, Laaksonen M, Zhu K, Enneman AW, McEvoy M, Peel R, Sham PC, Jaworski M, Johansson A, Hicks AA, Pludowski P, Scott R, Dhonukshe-Rutten RA, van der Velde N, Kähönen M, Viikari JS, Sievänen H, Raitakari OT, González-Macías J, Hernández JL, Mellström D, Ljunggren O, Cho YS, Völker U, Nauck M, Homuth G, Völzke H, Haring R, Brown MA, McCloskey E, Nicholson GC, Eastell R, Eisman JA, Jones G, Reid IR, Dennison EM, Wark J, Boonen S, Vanderschueren D, Wu FC, Aspelund T, Richards JB, Bauer D, Hofman A, Khaw KT, Dedoussis G, Obermayer-Pietsch B, Gyllensten U, Pramstaller PP, Lorenc RS, Cooper C, Kung AW, Lips P, Alen M, Attia J, Brandi ML, de Groot LC, Lehtimäki T, Riancho JA, Campbell H, Liu Y, Harris TB, Akesson K, Karlsson M, Lee JY, Wallaschofski H, Duncan EL, O'Neill TW, Gudnason V, Spector TD, Rousseau F, Orwoll E, Cummings S, Wareham NJ, Rivadeneira F, Uitterlinden AG, Prince RL, Kiel DP, Reeve J, Kaptoge SK. Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet. 23:3054-3068,2014.
8 Sillanpää E, *Cheng S, Häkkinen K, Finni T, Walker S, Pesola A, Ahtiainen J, Stenroth L, Selänne H, Sipilä S. Body composition in 18 to 88-year-old adults - comparison of multifrequencybioimpedance and dual-energy X-ray absorptiometry. Obesity (Silver Spring).22:101-109,2014.
9 Ojanen X, Borra RJ, Havu M, Cheng SM, Parkkola R, Nuutila P, Alen M, *Cheng S. Comparison of vertebral bone marrow fat assessed by 1H MRS and in-phase and out-of-phase MRI among family members. Osteoporos Int. 25:653-622,2014.
10 Wen H, Dou Z, Cheng S, Qiu W, Xie L, Yang H. Activity of thigh muscles during static and dynamic stances in stroke patients: a pilot case-control study. Top Stroke Rehabil. 21:163-72. doi: 10.1310/tsr2102-163,2014.
11 Krachler B, Völgyi E, Savonen K, Tylavsky FA, Alén M, *Cheng S. BMI and an Anthropometry-Based Estimate of Fat Mass Percentage Are Both Valid Discriminators of Cardiometabolic Risk: A Comparison with DXA and Bioimpedance. J Obes. 862514. doi: 10.1155/2013/862514,2013.
12 Wang R, Alen M, Yu Z, Wiklund P, Cheng SM, Törmäkangas T, Chen P, *Cheng S. Does Serum 25-Hydroxyvitamin D Influence Muscle Development during Puberty in Girls? - A 7-Year Longitudinal Study. PLoS One. 8:e82124,2013.
13 Toivonen MH, Pöllänen E, Ahtiainen M, Suominen H, Taaffe DR, Cheng S, Takala T, Kujala UM, Tammi MI, Sipilä S, Kovanen V. OGT and OGA expression in postmenopausal skeletal muscle associates with hormone replacement therapy and muscle cross-sectional area. Exp Gerontol. 48:1501-1504,2013.
14 Pekkala S, Wiklund PK, Hulmi JJ, Ahtiainen JP, Horttanainen M, Pöllänen E, Mäkelä K, Kainulainen H, Häkkinen K, Nyman K, Alén M, Herzig KH, Cheng S. Are Skeletal Muscle FNDC5 Gene Expression and Irisin Release Regulated by Exercise and Related to Health? J Physiol. 591:5393-5400,2013.
15 Tan X, Saarinen A, Mikkola TM, Tenhunen J, Martinmäki S, Rahikainen A, *Cheng S, Eklund N, Pekkala S, Wiklund P, Munukka E, Wen X, Cong F, Wang X, Zhang Y, Tarkka I, Sun Y, Partinen M, Alen M, *Cheng S. Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial. Trials. 14:235-243,2013.
16 Kujala UM, Mäkinen VP, Heinonen I, Soininen P, Kangas AJ, Leskinen TH, Rahkila P, Würtz P, Kovanen V, Cheng S, Sipilä S, Hirvensalo M, Telama R, Tammelin T, Savolainen MJ, Pouta A, O'Reilly PF, Mäntyselkä P, Viikari J, Kähönen M, Lehtimäki T, Elliott P, Vanhala MJ, Raitakari OT, Järvelin MR, Kaprio J, Kainulainen H, Ala-Korpela M. Long-term Leisure-time Physical Activity and Serum Metabolome. Circulation. 127:340-348,2013.
17 Moilanen P, Määttä M, Kilappa V, Xu L, Nicholson PH, Alén M, Timonen J, Jämsä T, Cheng S. Discrimination of fractures by low-frequency axial transmission ultrasound in postmenopausal females. Osteoporos Int. 24:723-730,2013.
18 Lu C, Ivaska KK, Alen M, Wang Q, Törmäkangas T, Xu L, Wiklund P, Mikkola TM, Pekkala S, Tian H, Väänänen HK, *Cheng S. Serum Osteocalcin Is Not Associated with Glucose but Is Inversely Associated with Leptin across Generations of Nondiabetic Women. J ClinEndocrinolMetab.97:4106-4114,2012.
19 Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, González-Macías J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren O, Lorenc RS, Marc J, Mellström D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Lagboom PE, Tang NL, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg E, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina-Gómez C, ThPalsson S, Reppe S, Rotter JI, Sigurdsson G, van Meurs JB, Verlaan D, Williams FM, Wood AR, Zhou Y, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Gudnason V, Hofman A, Jackson RD, Jones G, Jukema JW, Khaw KT, Lehtimäki T, Liu Y, Lorentzon M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson GC, Oostra BA, Peacock M, Pols HA, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, ShuldinerAR,Tylavsky FA, van Duijn CM, Wareham NJ, Cupples LA, Econs MJ, Evans DM, Harris TB, Kung AW, Psaty BM, Reeve J, Spector TD, Streeten EA, Zillikens MC, Thorsteinsdottir U, Ohlsson C, Karasik D, Richards JB, Brown MA, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 44:491-501,2012.
20 Tikanen O, Hu M, Vilavuo T, Tolvanen P, *Cheng S, Finni T. Ventilatory threshold during incremental running can be estimated using EMG shorts. Physiol Meas. 33:603-614,2012.
21 Munukka E, Wiklund P, Pekkala S, Völgyi E, Xu L, Cheng S, Lyytikäinen A, Marjomäki V, Alen M, Vaahtovuo J, Keinänen-Kiukaanniemi S, *Cheng S. Women with and without metabolic disorder differ in their gut microbiota composition. Obesity (Silver Spring). 20:1082-1087,2012.
22 Yu ZS, Völgyi E, Wang R, Ember A, Wiklund P, Alen M, Tylavsky FA, *Cheng S. Comparison of heart rate monitoring with indirect calorimetry for energy expenditure evaluation. JSHS .1: 178-183,2012.
23 Wiklund PK, Xu L, Wang Q, Mikkola T, Lyytikäinen A, Völgyi E, Munukka E, Cheng SM, Alen M, Keinänen-Kiukaanniemi S, *Cheng S. Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int. 23:1939-1945,2012.
24 Wiklund P, Xu L, Wang Q, Lyytikäinen A, Völgyi E, Munukka E, Cheng SM, Alen M, Keinänen-Kiukaanniemi S, *Cheng S. Prolonged breastfeeding protects mothers from later life obesity and related cardio-metabolic disorders. Pub Health Nutr . 15:67-74,2012.
25 *Cheng S, Kujala UM. Exercise in type 2 diabetes: The mechanisms of resistance and endurance training. JSHS 1: 2012:65-66.
26 Xu L, Wang Q, Wang Q, Lyytikäinen A, Mikkola T, Völgyi E, Cheng S, Wiklund P, Munukka E, Nicholson P, Alén M, *Cheng S. Concerted actions of insulin-like growth factor-1, testosterone and estradiol on peripubertal bone growth - A 7-year longitudinal study. J Bone Miner Res. 26:2204-2211,2011.
27 Völgyi E, Alén M, Xu L, Lyytikäinen A, Wang Q, Munukka E, Wiklund P, Tylavsky FA, *Cheng S. Effect of long-term leisure time physical activity on lean mass and fat mass in girls during adolescence. J Appl Physiol. 110:1211-1218,2011.
28 Wang Q, Xu L, Wang Q, Chen D, Tian H, Lu C, Cheng S, Völgyi E, Wiklund P, Munukka E, Nicholson P, Alén M, *Cheng S. Is bone loss the reversal of bone accrual? Evidence from a cross-sectional study in daughter-mother-grandmother trios. J Bone Miner Res. 26:934-940,2011.
29 Wang Q, Xu L, Wang Q, Chen D, Tian H, Lu C, Cheng S, Völgyi E, Wiklund P, Munukka E, Nicholson P, Alén M, *Cheng S. Is bone loss the reversal of bone accrual? - Evidence from a cross-sectional study in daughter-mother-grandmother trios. J Bone Miner Res. 26:934-940,2011.
30 Völgyi E, Lyytikäinen A, Tylavsky FA, Nicholson PHF, Suominen H, Alén M, Cheng S. Long term leisure time physical activity has a positive effect on bone mass gain in girls J Bone Miner Res. 25:1034-1041,2010.
31 Xu L, Nicholson P, Wang QJ, Wang Q, Alén M, *Cheng S. Fat mass accumulation compromises bone adaptation to load in Finnish women - a cross-sectional study spanning three generations. J Bone Miner Res. 25:2341-2349,2010.
32 Wang Q, Alén M, Lyytikäinen A, Xu L, Tylavsky FA, Kujala UM, Kröger H, Seeman E, *Cheng S. Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life. J Bone Miner Res. 25:1512-1520,2010.
33 *Cheng S, Völgyi E, Tylavsky F, Lyytikäinen A, Törmäkangas T, Xu LT, Cheng SM, Kröger H, Alen M, Kujala UM. Trait-specific tracking and determinants of body composition: a 7-year follow-up study of pubertal growth in girls. BMC Medicine. 7:5,2009.
34 *Cheng S, Xu L, Nicholson PHF, Tylavsky F, Lyytikäinen A, Wang Q, Suominen H, Kujala UM, Kröger H, Alen M. Low volumetric BMD is linked to upper-limb fracture in pubertal girls and persists into adulthood: A seven-year cohort study. Bone 45: 480-486,2009.
35 Wang Q, *Cheng S, Alén M, Seeman E, and The Finnish Calex-Study Group. Bone's structural diversity in adult females is established before puberty. J Clin Endocrinol Metab. 94:1555-1561,2009.
36 Xu LT, Nicholson PF, Wang Q, Alen M. *Cheng S. Bone and muscle development during puberty in girls - A 7-year longitudinal study. J Bone Miner Res. 24:1693-1698,2009.
37 Hu M, Finni T, Zou L, Perhonen M, Sedliak M, Alen M, *Cheng S. Effects of strength training on work capacity and parasympathetic heart rate modulation during exercise in physically inactive men. Int J Sports Med. 30:1– 6,2009.
38 Zheng A, Sakari R, Cheng SM, Hietikko A, Fagerlun KM, Moilanen P, Timonen J, Kärkkäinen M, Alen M, *Cheng S. Effects of a low-frequency sound wave therapy program on functional capacity, blood circulation, and bone metabolism in frail old men and women. Clin Rehabil. 23:897-908,2009.
39 Finni T, *Cheng S. Variability in lateral positioning of surface EMG electrodes. J Appl Biomech. 25:396–400,2009.
40 Völgyi E, Tylavsky FA, Lyytikäinen A, Suominen H, Alén M, *Cheng S. Assessing body composition with DXA and bioimpedance: effects of obesity, physical activity, and age. Obesity. 16:700-705,2008.
41 Finni T, Havu M, Sinha S, Usenius JP, *Cheng S. Mechanical behavior of the quadriceps femoris muscle tendon unit during low-load contractions. J Appl Physiol. 104:1320-1328,2008.
42 Suuriniemi M, Suominen H, Mahonen A, Alén M, *Cheng S. Estrogen receptor  polymorphism modifies the association between childhood exercise and bone mass: Follow-up study. Pediatric Ex Sci. 19:444-458,2007.
43 Finni T, Hu M, Kettunen P, Vilavuo T, *Cheng S. Measurement of EMG activity with textile electrodes embedded into clothing. Physiol Meas. 28:1405-1419,2007.
44 Wang Q, Alén M, Nicholson P, Halleen J, Alatalo S, Olsson C, Suominen H, *Cheng S. Differential effects of sex hormones on peri- and endocortical bone surfaces in pubertal girls.. J Clin Endocrinol Metab. 91:277-282,2006.
45 *Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alen M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PHF, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F. Effect of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial. Am J Clin Nutr 82:1115-1126,2005.
46 Lyytikäinen A, Lamberg-Allardt C, Kannas L, *Cheng S. Food consumption and nutrient intakes with a special focus on milk product consumption in early pubertal girls in Central-Finland. Pub Health Nutr 8:284-289,2005.
47 Tylavsky FA, Ryder KA, Lyytikainen A, Cheng S. Vitamin D, parathyroid hormone, and bone mass in adolescents. J Nutr. 135:2735S-2738S,2005.
48 Suuriniemi M, Mahonen M, Kovanen V, Alén M, Lyytikäinen A, Wang Q, Kröger H, *Cheng S. Association between exercise and pubertal BMD is modulated by estrogen receptor  genotype. J Bone Miner Res 19:1758-1765,2004.
49 *Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikianen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C. Association of low 25-hydroxy-vitamin D concentration with elevated parathyroid hormone concentration and low cortical bone density in early pubertal Finnish girls. Am J Clin Nutr. 78:485-492,2003.
50 Suuriniemi M, Mahonen A, Kovanen V, Alen M, *Cheng S. Relation of PvuII site polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls. Physiol Genomics. 15:217-24,2003.

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